Mechanisms and therapeutic potential of hydrogen sulfide in traumatic central nervous system injuries.

Traumatic central nervous system injuries encompass brain and spinal cord injuries. Recent studies have identified hydrogen sulfide (H₂S) as a potent endogenous gasotransmitter with multifaceted roles in neuroprotection and central nervous system repair. In this systematic review, we explore the mechanisms and therapeutic potential of H₂S in traumatic central nervous…

Inflammation-targeted nanoplatform: NIR-II imaging-guided encephalitis suppressing by dual antioxidant-ferroptosis action.

Encephalitis, a life-threatening neurological disorder with high mortality and debilitating long-term sequelae, remains a formidable clinical challenge due to limited therapeutic strategies targeting its underlying pathological mechanisms. Current interventions, constrained by blood-brain barrier (BBB) impermeability and a focus on symptomatic relief, fail to mitigate ferroptosis and reactive oxygen species (ROS)-mediated…

Multifunctional exosome-driven tumor immunotherapy sensitization: converting intratumoral bacteria into antitumor fighters.

Utilizing intratumoral bacteria to reprogram tumor-associated macrophages (TAMs) into a tumoricidal M1 phenotype holds great potential in cancer immunotherapy. However, intratumoral bacteria cunningly hide inside tumor cells to evade the surveillance of TAMs. Herein, we utilize dead tumor cells as bridges to connect TAMs with intratumoral bacteria. We constructed a…

“Restauro” strategy: Siderophore-like antibiofilm coating combats prosthetic joint infection and preserves implants via bacterial ferroptosis-like death.

Prosthetic joint infection (PJI) treatment failure primarily stems from incomplete biofilm removal and antibiotic resistance. Addressing these challenges, antibiotic-independent antimicrobials become preferred weapons. Meanwhile, iron metabolism provides an area of interest, due to its essentiality in biofilm formation. Tannic acid (TA), a plant-derived polyphenol, whose siderophore-like antibacterial mechanism is first…

Blood-testis barrier-crossing extracellular vesicles for asthenozoospermia therapy via synergistic ATP replenishment and ferroptosis suppression.

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, poses significant therapeutic challenges due to the restrictive blood-testis barrier (BTB). To address this limitation, we engineered multifunctional extracellular vesicles (EVs) derived from umbilical cord mesenchymal stem cells, loaded with adenosine triphosphate (ATP) to synergistically restore cellular bioenergetics…

Microalgae-MOF integrated drug delivery system for cranial radiotherapy and chemotherapy-induced brain injury.

The combination of cranial radiotherapy and chemotherapy may cause brain damage and cognitive dysfunction, therefore developing protective strategies for the treatment of chemoradiotherapy-induced brain injury is of great significance. Deferoxamine is an efficient iron chelator to inhibit ferroptosis which induced by radiotherapy and chemotherapy, but it has low oral bioavailability…

Corrigendum to “Lactate metabolism regulating nanosystem synergizes cuproptosis and ferroptosis to enhance cancer immunotherapy” [Biomaterials 325 (2026) 123538].

Lnc_011797 promotes ferroptosis and aggravates white matter lesions.

JOURNAL/nrgr/04.03/01300535-202605000-00036/figure1/v/2025-10-21T121913Z/r/image-tiff Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear. Long non-coding RNAs (lncRNAs) have been shown to influence the occurrence and development of these lesions.…

The critical role of iron homeostasis in neurodegenerative diseases.

Neurodegenerative diseases are prevalent conditions that greatly impact human health. These diseases are primarily characterized by the progressive loss and eventual death of neuronal function, although the precise mechanisms underlying these processes remain incompletely understood. Iron is an essential trace element in the human body, playing a crucial role in…

Cell-based therapies for traumatic optic neuropathy: Recent advances, challenges, and perspectives.

Traumatic optic neuropathy is a form of optic neuropathy resulting from trauma. Its pathophysiological mechanisms involve primary and secondary injury phases, leading to progressive retinal ganglion cell loss and axonal degeneration. Contributing factors such as physical trauma, oxidative stress, neuroinflammation, and glial scar formation exacerbate disease progression and retinal ganglion…