Latest Research Papers
Coal Dust Nanoparticles Induce Colitis-Like Lesions in Rats via Gut Microbiota Dysbiosis and P53/SCO2/SLC7A11-Mediated Epithelial Ferroptosis.
Advanced mining technologies have increased the generation and exposure risk of coal dust nanoparticles (CD-NPs). While CD-NPs are known to cause lung damage, their effects on intestinal tissues following respiratory exposure remain unclear. Here, we investigated the damaging effects of CD-NPs on colonic tissues and the underlying mechanisms.
Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.
Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood. Early immune checkpoint inhibitors have delivered significant clinical benefit, but their efficacy and durability remain limited in many patients. These limitations have driven the exploration of next-generation immune checkpoints…
Self-Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication.
Ferroptosis and cuproptosis, two emerging forms of metal-dependent cell death, show potential in combating multidrug-resistant bacterial infections. However, their effectiveness is constrained by insufficient intracellular iron/copper levels, unintended toxicity to healthy cells. Here, we developed a self-amplifying, targeted nanocomposite (ct@HMCF-Dex) based on hollow mesoporous copper-iron sulfide (HMCF), citric acid (ct),…
Biological Mechanisms of Microwave Ablation in Thyroid Tumors and Its Induced Immunomodulatory Effects.
Microwave ablation (MWA) is a minimally invasive thermal ablation technique that eradicates thyroid tumors by rapidly increasing tissue temperature to 60-100 degrees Celsius (°C) through dielectric hysteresis. This focused electromagnetic heating leads to irreversible protein denaturation, cell membrane disruption, and coagulative necrosis. Within the ablation zone, mitochondria and the endoplasmic…
Resistance by Inhibiting the STAT3/SLC25A27 Pathway and Promoting Ferroptosis in Hepatocellular Carcinoma.
Lenvatinib is the first-line drug used in the systemic treatment of advanced hepatocellular carcinoma (HCC), although its therapeutic efficacy is limited by emerging resistance mechanisms. Our study aims to investigate the molecular pathways underlying lenvatinib resistance in HCC to inform circumvention strategies for therapeutic resistance. Our findings demonstrated that solute carrier…
Protective Effect of Pentoxifylline Against High Glucose-Induced Ferroptosis in Vascular Smooth Muscle Cells.
Ferroptosis has emerged as a pivotal form of regulated cell death implicated in diabetic vascular complications, yet the upstream transcriptional mechanisms governing this process remain insufficiently defined. Chronic hyperglycemia induces oxidative stress, iron overload, and vascular remodeling, but how these metabolic disturbances trigger ferroptotic signaling in vascular smooth muscle cells…
Aromatic amino acid metabolism shapes autophagy-mediated adaptation to iron deprivation in glioblastoma cells.
Glioblastoma (GBM) displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in GBM remains incompletely understood. Deferoxamine (DFO), an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of autophagy, apoptosis, and ferroptosis under DFO-induced stress is…
Correction: PPARa-FSP1 axis modulates lipid peroxidation-induced neuronal ferroptosis to promote functional recovery in mouse model of traumatic spinal cord injury.
S-equol promotes ferroptosis in triple negative breast cancer by coordinating NCOA4-mediated ferritinophagy and PPARγ-mediated lipid metabolism.
Triple negative breast cancer (TNBC) is a diverse and highly aggressive cancer characterized by a strong tendency to metastasize, poor prognosis, and a lack of effective therapeutic targets. S-equol, an active metabolinte produced by gut microbiota through the conversion of daidzein, has been proven to possess anticancer activity. This study…