Latest Research Papers
USP7/SETDB1 promotes non-small cell lung cancer progression by regulating ferroptosis via NRF2/SLC7A11/GPX4 axis.
Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Given the reported associations of both SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) with various cancers and ubiquitin-specific protease 7 (USP7) with NSCLC progression, this study aims to elucidate the role of SETDB1 and USP7…
Nrf2 as a therapeutic target of ginseng: A comprehensive review from preclinical evidence to clinical applications.
Ginseng is a traditional herb that has been widely used for centuries to treat various diseases. A key mechanism of ginseng is the activation of nuclear factor erythroid 2-like 2 (Nrf2), a master regulator of antioxidant gene expressions. Activation of Nrf2 helps maintain redox homeostasis, which is crucial for chronic…
Multi-omics identifies a VIM-associated microglial program linked to lactylation, ferroptosis, and neuroinflammation after spinal cord injury.
The secondary injury cascade following spinal cord injury (SCI) involves substantial metabolic reprogramming and immune responses. However, whether transcriptional signatures related to lactylation, ferroptosis, and neuroinflammation show coordinated changes after SCI, and which cellular states are associated with these signatures, remain unclear.
The research landscape of ferroptosis in ischemic stroke: a bibliometric analysis of the literature from 2017 to 2025 based on the WOS and PubMed databases.
Ischemic stroke is a leading cause of disability and mortality worldwide. Ferroptosis-an iron-dependent, lipid peroxidation-driven programmed cell death-has emerged as a key contributor to post-stroke neuronal injury, with research expanding rapidly since 2017.
A panoramic analysis of keloid pathogenesis: multidimensional network regulation of genetics-immunity-metabolism-mechanical force.
Keloid, as a unique form of pathological scar, involves complex interactions across multiple dimensions in its pathogenesis, including genetic susceptibility, epigenetic regulation, immune microenvironment disorders, metabolic reprogramming, abnormal mechanical force transduction, and fine-tuning by non-coding RNAs. At the genetic level, alleles such as HLA-DRB1*15, HOX gene family, and high-frequency mutation…
The estrogen-ferroptosis axis in postmenopausal osteoporosis, osteoarthritis, and intervertebral disc degeneration: shared mechanisms and emerging evidence.
Estrogen deficiency is a major risk factor for degenerative disorders of the musculoskeletal system in postmenopausal women, while ferroptosis, an iron-dependent form of programmed cell death, has been implicated in the pathogenesis of various osteoarticular diseases. Recent studies indicate an interplay between estrogen signaling and ferroptosis, with evidence relatively well…
Matrine Alleviates Sepsis-Induced Acute Lung Injury by Reinforcing NQO1/SLC7A11/GPX4-Associated Anti-Ferroptotic Defenses and Attenuating NF-κB-Driven Inflammation.
Sepsis triggers dysregulated systemic inflammation and multiple-organ dysfunction, with the lungs being particularly susceptible to injury. Sepsis-induced acute respiratory distress syndrome (ARDS) is mainly driven by TLR4/NF-κB-mediated hyperinflammation and alveolar macrophage activation. Matrine, a bioactive alkaloid derived from , has been reported to modulate redox homeostasis and ferroptosis-associated lipid peroxidation.…
Gut microbiota-regulated cell death: a review on pyroptosis, ferroptosis, and related mechanisms.
The intestinal microbiota has emerged as a crucial regulator of host physiological functions, significantly influencing various forms of regulated cell death (RCD). Among these, pyroptosis and ferroptosis play pivotal roles in immune regulation, metabolic homeostasis, and disease progression. The gut microbiota modulates these cell-death pathways through microbial metabolites, inflammatory signaling,…
Itraconazole induced ferroptosis in acute myeloid leukemia cells through TP53INP1.
Itraconazole (ITRA) is a broad-spectrum antifungal agent approved by the Food and Drug Administration (FDA). It has been shown to inhibit cancer growth, but the underlying molecular mechanism of itraconazole-induced cell death in acute myeloid leukemia (AML) remains largely elusive.
Mechanistic Investigation of Salidroside Modulates Iron Overload to Mitigate Radiation-Induced Heart Disease.
Radiation-induced heart disease (RIHD) severely compromises the long-term survival of cancer patients. Although ferroptosis has been implicated as a key contributor to RIHD pathogenesis, the underlying regulatory mechanisms remain incompletely defined. Prompted by clinical observations of elevated serum iron concentrations following thoracic radiotherapy, this study investigated iron-metabolic alterations during RIHD…