The Indicine X-linked CYBBL237M Mutation Can Suppress Intracellular Infection with Tubercle Bacilli.

Indicine cattle exhibit superior resistance to Mycobacterium bovis infection compared to taurine breeds, revealing divergent genetic mechanisms underlying bovine tuberculosis (bTB) resilience. Previous research has demonstrated that Cytochrome b-245 (CYBB) gene variants are associated with Mendelian susceptibility to Mycobacterium tuberculosis complex (MTBC) infections. In this study, we analyzed the X-chromosomal…

YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation.

Aseptic loosening and periprosthetic osteolysis driven by wear particles are major causes of total joint arthroplasty (TJA) failure. Investigating the upstream mechanisms of osteoblast ferroptosis in periprosthetic osteolysis is essential for developing therapeutic strategies to lengthen the lifespan of artificial joints.

Metformin-amplified ferroptosis induced by ultrasmall manganese ferrite nanoparticles: a GPX4-independent strategy for prostate cancer therapy.

Immunohistochemical investigation of transferrin receptor 2 (TFR2) immunoreactivity in patients with cutaneous lichen planus.

Lichen planus (LP) is a chronic inflammatory dermatosis with an unclear pathogenesis. Recent studies suggest that iron metabolism, oxidative stress, and ferroptosis mechanisms may play a role in the development of LP. Transferrin Receptor 2 (TFR2), an important receptor in iron homeostasis, may contribute to these processes.

NSC777201 exhibits anticancer activity against colorectal cancer cells by inducing multiple types of cell death.

The prognostic significance of lymph node metastasis-related genes in pancreatic adenocarcinoma is associated with immune cell infiltration and ferroptosis.

The objective of this study is to investigate the genes associated with lymph node metastasis of Pancreatic adenocarcinoma (PAAD) and their correlation with immune infiltration and ferroptosis. The differentially expressed genes associated with lymphatic metastasis of PAAD were analyzed based on the cancer genome atlas database. The protein-protein interaction network…

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma.

Lung adenocarcinoma (LUAD) displays marked intratumoral heterogeneity with distinct histological patterns. The solid pattern representing poorly differentiated LUAD is linked to poor prognosis and therapeutic resistance. To uncover underlying mechanisms, we integrate bulk and single-cell RNA sequencing and identify a preferential enrichment of interleukin 4 induced 1 (IL4I1)-expressing tumor-associated macrophages…

Cell Membrane Biomimetic Drug Delivery Systems Based on Ferroptosis Mechanism for Anticancer Treatment.

Ferroptosis, a recently identified iron-dependent form of programmed cell death that is distinct from apoptosis, holds significant promise for the eradication of invasive malignant tumors that are resistant to conventional therapies. However, many ferroptosis inducers utilized in vivo face considerable challenges, including immune clearance, insufficient targeting, and poor biocompatibility. Biomimetic…

Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer.

The Hippo pathway effector Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) play a critical role in promoting lung cancer progression, but paradoxically increase tumor cell sensitivity to ferroptosis, a form of lipid peroxidation-driven cell death. The mechanism through which YAP/TAZ-high cells evade ferroptosis during cancer progression remains…

Maternal intestinal and placental mitochondrial dysfunction, autophagy, and ferroptosis involving intestinal microbiota by gut microbiota transplantation from sheep to mice.

Exposure to testosterone (T) in pregnant ewes resulted in placental dysfunction and fetal growth restriction (FGR). However, the impact of T on gut microbiota and its contribution to exacerbating intestinal and placental pathologies remains uncharacterized. Pregnant sheep received intramuscular injections of 100 mg T propionate or a control vehicle. To examine the…