Latest Research Papers
Manganese Biomineralized Ferritin Nanoplatforms with Shielding and Stimuli-Responsive Release for Potentiated Ferroptosis and Multimodal Ovarian Cancer Therapy.
Natural ferritin Fn) is a cage-like protein with a central cavity, making it a promising vehicle for drug delivery. However, its non-specific accumulation in iron-metabolizing organs impairs targeting precision and therapeutic efficacy. To overcome this challenge, we aimed to develop a novel biomimetic nanoplatform based on manganese-mineralized ferritin loaded with…
Acute high-temperature stress induces oxidative stress, ferroptosis, and metabolic homeostasis changes in the gills of Trachinotus ovatus.
Fish are ectothermic animals that are highly sensitive to water temperature fluctuations, and elevated temperatures can readily trigger stress responses. Gills, the primary organ for respiration and osmoregulation in fish, are directly exposed to the water environment and therefore highly susceptible to high-temperature (HT) stress. In this study, the juvenile…
RNA biomarkers in hemorrhagic stroke.
Hemorrhagic stroke (HS), characterized by the rupture of cerebral blood vessels and bleeding into brain tissue, leads to high mortality and morbidity, necessitating improved methods for diagnosis, prognosis, and treatment. This chapter explores the pivotal role of ribonucleic acids (RNAs), particularly non-coding RNAs (ncRNAs) like microRNAs (miRNAs), long non-coding RNAs…
FAM96A functions as a novel pace controller for iron uptake to maintain iron homeostasis and erythropoiesis.
Iron is indispensable for various biological processes, among which erythropoiesis is a privileged iron consumer to synthesize hemoglobin. FAM96A, also known as cytosolic iron-sulfur protein assembly 2 A (CIA2A), is a conserved protein involved in cytosolic iron-sulfur cluster assembly but also harboring a canonical signal peptide for secretion. Here, we unveil…
GSH-responsive triple-action photosensitizer nanoplatforms orchestrate cuproptosis-ferroptosis synergy to potentiate antitumor PDT efficacy.
Multimodal targeted combination therapy that harnesses synergistic effects has emerged as a transformative paradigm in cancer therapy, progressively replacing traditional monotherapy. Herein, we report a tumor microenvironment (TME)-responsive multifunctional nanoplatform Cu-Ce6@DHA NPs (CCD NPs), which is self-assembled through the coordination of Cu²⁺, the antitumor drug dihydroartemisinin (DHA), and the photosensitizer…
Metal-Organic Framework DNA Hydrogel Microspheres Enable Ferroptosis-Based Therapy for Esophageal Squamous Cell Carcinoma.
Esophageal squamous cell carcinoma (ESCC) remains a challenging malignancy due to limited therapeutic efficacy of conventional chemotherapy, which is often hampered by drug resistance and systemic toxicity. Ferroptosis, an iron-dependent regulated cell death mechanism, has emerged as a promising strategy for cancer treatment. Curcumin, a natural compound with demonstrated anticancer…
Oxime Sulfonates-Based Photoinitiator Activates Pyroptosis and Ferroptosis for Hypoxia Tumor Therapy.
The development of biocompatible and efficient photo-triggered hydrogen abstraction systems holds considerable promise for the oxidation of NADH, thereby disrupting the NADH/NAD+ balance, modulating redox homeostasis, and advancing therapeutic approaches for hypoxic tumors. In this study, an oxime sulfonate-based hydrogen abstraction photoinitiator (TSA) is designed to induce pyroptosis and ferroptosis…
A harmless-to-harmful switchable and spatiotemporally activated nano-CRISPR hierarchically amplifies ferroptosis in melanoma.
Ferroptosis therapy faces challenges due to low lipid peroxide (LPO) levels. Herein, we develop a harmless-to-harmful switchable and spatiotemporally activated nano-CRISPR system (termed ARCHER) that sequentially amplifies ferroptosis sensitivity, iron ion levels, and reactive oxygen species (ROS) to amplify ferroptosis therapy efficiency. ARCHER targets cancer cells and releases CRISPR-Cas9 and…
Ginsenoside Rg1 antagonizes diabetic osteoporosis by regulating ferroptosis via mitochondrial membrane potential in H-type vascular endothelial cells.
Endothelial dysfunction under high-glucose conditions is a key pathological process contributing to the development and progression of diabetic osteoporosis (DOP). High glucose-induced damage to H-type vascular endothelial cells (H-type ECs), including mitochondrial dysfunction, increased lipid peroxidation, and activation of ferroptosis, is considered a potential mechanism underlying bone loss and dysregulated…
Ferroptosis and microglial polarization in retinal vein occlusion: pathological mechanisms and therapeutic strategies.
With the acceleration of global aging, the incidence of retinal vein occlusion (RVO) has risen markedly. Its pathogenic mechanisms are closely linked to iron dyshomeostasis and microglial polarization and age-related degenerative changes in retinal microvessels. We systematically summarize the regulatory mechanisms of ferroptosis-an iron-dependent, lipid peroxidation-driven form of cell death,…