Latest Research Papers
MircoRNAs as regulators of regulated cell death in cancer progression: a focus on ferroptosis, anoikis and pyroptosis.
Cancer progression is shaped not only by genetic alterations but also by dynamic remodeling of regulated cell death. MicroRNAs (miRNAs) have emerged as central regulators of these processes by coordinating gene expression, metabolic balance, and stress responses. This review summarizes current understanding of how miRNAs modulate ferroptosis, anoikis, and pyroptosis…
Demethoxycurcumin Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Nrf2-Mediated Anti-Inflammation and Ferroptosis Inhibition.
Sepsis-induced acute lung injury (SI-ALI) represents a life-threatening condition driven by dysregulated immune responses and redox imbalance. Demethoxycurcumin (DMC), a bioactive analog of curcumin, exhibits marked anti-inflammatory and free radical-scavenging capacities. Despite its potential, the precise molecular pathways through which DMC mitigates SI-ALI pathogenesis have yet to be fully elucidated.
Cell-Free Supernatant of Porphyromonas gingivalis Promotes the Malignancy of Oral Squamous Cell Carcinoma by Suppressing Ferroptosis.
Oral squamous cell carcinoma (OSCC) is a series global health concern. Porphyromonas gingivalis (P.g), a major pathogenic bacterium, promotes tumorigenesis and progression. Ferroptosis is also closely related to the progression of tumors. Therefore, this study aimed to investigate whether P.g cell-free supernatant (Pg-SN) alters ferroptosis and malignant phenotypes in OSCC…
Circ_STIL Affects Ferroptosis by Sponging miR-338-3p in Oral Squamous Cell Carcinoma.
Ferroptosis is pivotal in cancer onset and progression, which can be mediated by non-coding RNAs.
MGAT5 regulates ferroptosis via the Nrf2/HO-1 signaling pathway in diabetic nephropathy.
Diabetic nephropathy (DN) is a major complication of diabetes mellitus, and identifying effective therapeutic targets remains an urgent need. In this study, genes associated with DN were obtained from the gene expression omnibus (GEO) database, and Bioinformatics analysis revealed that mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (MGAT5) was downregulated in DN. Functional experiments…
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration.
The impaired regenerative capacity of osteoporotic individuals poses a significant challenge to the repair of bone defects. In the osteoporotic microenvironment, low pH, excessive reactive oxygen species (ROS), and chronic inflammation create a self-perpetuating vicious cycle that impedes healing. However, conventional therapies fail to sustainably improve the damaged microenvironment. Here,…
Analysis of lipid-protein interactive oxidation and underlying pathways in aquatic products via multi-omics and machine learning: a case study of air-dried hairtail.
The interactive oxidation mechanisms between lipids and proteins during aquatic product processing remain poorly understood, limiting quality control strategies. This investigation employed a comprehensive approach by integrating multi-omics data with seven machine learning models to elucidate the mechanisms of lipid and protein interactive oxidation in air-drying hairtail. The optimal XGBoost…
, identified by a ferroptosis-related prognostic model, contributes to progression and drug resistance of esophageal cancer.
Esophageal cancer has a poor prognosis and limited treatment options. Ferroptosis, an iron-dependent cell death pathway, is a promising therapeutic target; however, its significance in esophageal cancer remains largely unexplored. Here, we investigated the prognostic significance of ferroptosis-related genes in esophageal cancer and identified a key functional regulator that may…
New insights into diagnostic values and mechanisms of ferroptosis associated with immune infiltration in diabetic kidney disease.
The pathogenesis of diabetic kidney disease (DKD) is complex and closely related to ferroptosis and immune dysregulation, but the relevance is unclear. The present study investigates the potential mechanisms of ferroptosis-related genes (FRGs) in DKD and their relationship with the immune-inflammatory response. It searches for new diagnostic biomarkers to help…
An hiPSC-derived multi-lineage lung model exhibiting proximal-distal epithelial features for modeling pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with limited therapeutic options. Existing hiPSC-derived lung organoid models are largely restricted to single epithelial lineages and cannot endogenously integrate multiple pulmonary cell types, limiting mechanistic studies and drug screening.