MiR-124 alleviates cerebral ischemia-reperfusion injury by targeting SLC1A5 to inhibit neuronal ferroptosis.

This study aimed to investigate whether miR-124 alleviates neurological injury in cerebral ischemia-reperfusion injury (CIRI) mice by targeting Solute Carrier Family 1 Member 5 (SLC1A5) to regulate ferroptosis.

N-Myristoylation: A Central Hub Integrating Tumor Signaling, Metabolism, and Immunity for Precision Therapy.

Lipid modifications are critical for membrane anchoring and signal transduction. N-myristoylation, catalyzed by NMT1/2, irreversibly attaches myristic acid to N-terminal glycine residues, enabling stable membrane localization and crosstalk with other post-translational modifications. This review traces NMT research from structural characterization to substrate profiling, highlighting the ordered double-substitution catalytic mechanism and…

Rhapontigenin Alleviates Sepsis-Associated Acute Kidney Injury and Is Accompanied by Modulation of Ferroptosis, Inflammation, and NF-κB Signaling.

Sepsis-associated acute kidney injury (SA-AKI) is a common complication in critically ill patients and is associated with high mortality. Evidence suggests that ferroptosis-related lipid peroxidation and inflammatory responses contribute to renal injury. The potential effects of rhapontigenin (Rha), a natural compound with antioxidant and anti-inflammatory properties, have not been directly…

6-Gingerol Regulates the Exosomal miR-148b-3p/ACSL4/Ferroptosis Axis in an in vitro Model of Diabetic Retinopathy.

Diabetic retinopathy (DR), a leading cause of blindness, is driven by redox imbalance and ferroptosis in retinal endothelial cells. While 6-Gingerol exhibits antioxidant properties, its role in modulating exosome-mediated redox signaling in DR remains unexplored. This study investigates whether 6-Gingerol protects against DR by regulating ferroptosis via the exosomal miR-148b-3p/ACSL4…

Smart Colloidal Systems as Drug Delivery and Therapeutic Modulation Platforms for Renal Cell Carcinoma.

Renal cell carcinoma (RCC) is one of the major malignant tumors of the genitourinary system and remains difficult to treat in advanced or recurrent settings. Although surgery, antiangiogenic targeted therapy, immune checkpoint blockade, mTOR inhibition, and HIF-2α-targeted therapy have improved clinical outcomes, recurrence, therapeutic resistance, heterogeneous tumor exposure, and systemic…

Ferroptosis in gastrointestinal stromal tumors.

Hydroxysafflor yellow A attenuates TBHP-induced lipid peroxidation and calcification-related changes in human endplate chondrocytes: involvement of SLC7A11/GPX4 signaling.

Intervertebral disc degeneration (IDD) is a chronic degenerative disorder, with oxidative stress being one of the primary driving mechanisms of IDD. Hydroxysafflor yellow A (HSYA), a major active component of safflower, exhibits potent antioxidant, anti-inflammatory, and anti-apoptotic properties. However, its role in IDD remains unclear. To explore the mechanism underlying…

Quercetin attenuates ferroptosis-associated myocardial injury in rats after coronary microembolization by activating the Nrf2/HO-1 signaling pathway.

Coronary microembolization (CME) significantly contributes to the progression of heart failure and is strongly associated with adverse clinical outcomes in patients. Ferroptosis has been implicated in CME-induced myocardial injury. Quercetin has well-documented anti-inflammatory and antioxidant properties and shows therapeutic potential in coronary artery disease. However, its precise mechanism for regulating…

Potential role of ferroptosis in sterile acute lung injury induced by a non-hypoxic ischemia-reperfusion insult.

Ferroptosis, a regulated form of necrotic cell death, is implicated in the pathogenesis of hypoxic lung ischemia-reperfusion injury (LIRI). However, its role in non-hypoxic LIRI, which occurs in common clinical conditions such as trauma and pulmonary embolism, remains unclear. Given that ferroptosis has been implicated in sterile inflammation and lipid…

Dual-Responsive Biomimetic Nanoplatform for Cascade Synergistic Therapy of Endometrial Cancer.

Endometrial cancer is a common malignant tumor in the female reproductive system. Traditional chemotherapy has limitations such as poor targeting, dose-limiting toxicity, and treatment intensity restrictions. To address these issues, this study constructed an intelligent nanoplatform-GOD-Fe3+&DOX-Membrane@Polymer (GOD-Fe3+&DM@Poly.)-based on reversible addition-fragmentation chain transfer (RAFT) polymerization technology. The incorporation of pyridine disulfide…