Latest Research Papers
An excitation-customized ICT-type turn-on probe for visualization of cysteine fluctuation in diverse drug-induced ferroptosis pathways.
Cysteine (Cys) acts as a key upstream regulator of cellular redox homeostasis and ferroptosis. Distinct ferroptosis inducers exert different effects on Cys metabolism. Erastin disrupts X-dependent cystine uptake to deplete cellular Cys and trigger ferroptosis, while RSL3 induces ferroptosis by impairing downstream lipid metabolism without disturbing Cys homeostasis. Thus, real-time…
The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.
This study employed a bidirectional 2-step, two-sample Mendelian randomization approach to investigate the causal relationships between ferroptosis-related genes and juvenile idiopathic arthritis (JIA) and to explore the mediating role of immune cells. Ferroptosis genes were identified from the deCODE database and matched with protein quantitative trait locus data as exposures…
FOXP1 exacerbates allergic rhinitis progression by mediating ferroptosis in nasal mucosal epithelial cells via transcriptional regulation of SDHAF2.
To investigate the role of the transcription factor FOXP1 and its target gene SDHAF2 in allergic rhinitis (AR), as well as their regulatory effects on ferroptosis in nasal epithelial cells.
Mitochondrial hub: the integrative axis connecting ferroptosis and metabolic reprogramming in periodontitis.
Periodontitis is a chronic inflammatory disease characterized by persistent periodontal tissue destruction and alveolar bone loss, which is closely associated with multiple systemic disorders. Emerging evidence indicates that ferroptosis and metabolic reprogramming are jointly involved in the progression of periodontitis; however, their causal linkage, hierarchical regulatory network, and unified core…
Recent advancements in NRF2-regulated ferroptosis modulation for targeted cancer therapy.
The nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway is a major regulator of cellular response to oxidative stress. While NRF2 protects the normal cells against oxidative stress, its abnormal signaling activity in the context of cancer helps tumor cells evade oxidative stress, survive, proliferate, and develop resistance to…
Targeting 3-mercaptopyruvate sulfurtransferase selectively eliminates colorectal cancer stem cells.
Cancer stem cells (CSCs) contribute to therapeutic resistance, metastatic progression, and tumor recurrence, yet the metabolic pathways that sustain their survival remain incompletely understood. Here, we identify 3-mercaptopyruvate sulfurtransferase (3-MST), a hydrogen sulfide-producing enzyme encoded by MPST, as a metabolic dependency of colorectal CSCs. 3-MST expression was increased in human…
Bioactive vitamin E-NAD conjugate nanoparticles for osteoarthritis management via simultaneous suppression of inflammation and oxidative stress.
The involvement of oxidative stress, inflammation, and energy metabolism disorders in osteoarthritis (OA) makes it challenging to handle these problems using a single therapeutic agent concurrently. Here, we report a tailored bioactive conjugate consisting of a hydrophobic radical-trapping antioxidant (vitamin E, VE), a hydrophilic nicotinamide adenine dinucleotide (NAD), and a…
Metal-sulfur metabolic derangement and regulated cell death in age-related cardiovascular diseases: mechanisms, biomarkers, and emerging interventions.
Cardiovascular ageing is accompanied by progressive impairment of redox buffering, mitochondrial quality control, proteostasis and metal homeostasis. Iron and copper homeostasis, together with cystine-glutathione and thiol/disulfide redox metabolism, are increasingly recognized as interconnected determinants of metabolic vulnerability and regulated cell death (RCD) in age-related cardiovascular diseases. Ferroptosis, defined by iron-dependent…
The redox paradox in neurological disorders: balancing cytoprotection, ferroptosis, and therapeutic targeting.
Neurological disorders, including ischaemic and haemorrhagic stroke, traumatic brain injury, and chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, represent a major global health burden. Despite diverse etiologies, these conditions share common pathological mechanisms driven by oxidative stress, neuroinflammation, mitochondrial dysfunction, iron dysregulation, and secondary neuronal…
Autophagy-mediated amplification of ferroptosis via a curcumin-loaded metal-enzyme nanoplatform for synergistic tumor therapy.
Ferroptosis is an iron-mediated cell death process driven by lipid peroxidation, yet its antitumor potential is often counteracted by the limited endogenous HO content, the strict catalytic conditions required for the Fenton reaction, and protective autophagy. Notably, sustained autophagy drives ferritin degradation and iron release, thereby amplifying ferroptotic signaling. To…